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GENOMICS

By Francesca De Nicola

The IRE Working Group (WG) Genomics is a multidisciplinary group spanning in expertise from basic-translational approaches to clinical Next Generation Sequencing (NGS). Although NGS is our main focus, members of the group implement many ancillary nucleic-acid-based methods for research and advanced diagnostics. Biologists, Biotechnologists, Bioinformaticians, Pathologists and Clinical Pathologists provide the WG Genomics with a solid biotech core, but all the activities (from study design to patient enrollment and treatment, through data collection and analysis) build on the strong contributions of medical oncologists, radiologists, surgeons, and Biostatisticians. Integrative approaches are being carried out including radiogenomics, liquid biopsies, whole-genome and single-cell sequencing, big data interrogation, model building and clinical trial design. The goal is to harmonize diverse skills and institutional needs into a common finalized effort (see figure).