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- Immune Metabolism Dysregulation and Efficacy of Anti-PD-1/PD-L1 Agents in Non-Small Cell Lung Cancer (NSCLC)
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- Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation after robot-assisted surgical treatment of genitourinary cancers
- Deciphering KEAPness for Improved Immunotherapy Prediction and Treatment
- MiRNA-based therapeutic approach to fight triple negative breast cancer
- Beyond the creation of a living biobank: dissecting the transcriptomic landscape of Gastro-entero-pancreatic neuroendocrine neoplasms
- Multidimensional assessment of virus-associated head and neck cancer patients for the discovery of predictive biomarkers to guide clinical intervention
- TArgeting drug resistant melanoma with miCroRNAs delivered by Lipid NanoparTICles (TACTIC)
- Addressing liver fibrosis prevention and treatment: an unbiased query on the hepatic microenvironment with a perspective targeting of the pro-fibrotic kinase HIPK2
- Analyses of HPV and host body fluid biomarkers as non-invasive strategy for detection of head and neck cancer relapse
- Deciphering Biology of R/R DLBCL Subtypes: miRNA Biomarkers for Optimizing Treatment and Survival
- Clinically approved drugs targeting pyruvate kinase M2: a drug repurposing pathway to move forward the treatment of glioblastoma
- Developing a Biobank Network Among Major Sarcoma Treatment Centers to Improve Biomedical Research
- Identification and Validation of Prognostic and Predictive Biomarkers, Including E3 Ubiquitin Ligases and MicroRNA Signature, for the Development of New Immunotherapeutic Approaches in Glioma
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- Exploring the role of Bcl-2 family in the immune surveillance of melanoma: from mechanisms to therapeutic perspectives
- Exploring how endothelin-1/PIEZO axis intersects mechanical forces to fuel PARP inhibitor resistance in ovarian cancer
Developing a Biobank Network Among Major Sarcoma Treatment Centers to Improve Biomedical Research
Project description
PI: Davide Maria Donati, Istituto Ortopedico Rizzoli
IRE Principal Collaborators Involved: Simona Di Martino
Project duration: 24 months
Project code: PNRR-TR1-2023-12377233
The project aims to develop a biobank network among major sarcoma treatment centers in Italy to enhance biomedical research. Biobanks are legal entities that manage the acquisition, storage, and distribution of biological samples and associated data, which are crucial for health and medical research.
Purpose
Establish a consolidated network among four major institutions to collect a significant number of samples and information to be shared according to current regulations.
Improve sarcoma knowledge and facilitate new research studies and future clinical trials.
Expected Outcomes
Implementation of existing biobanks: Integrate phenotypic, genomic, and clinical data to build the patient's clinical history, standardizing the IT infrastructure to allow sharing of biospecimens and related data among the operating units.
Creation of a new biobank: Establish a certified biobank at the AORN Santobono-Pausilipon Children's Hospital in Naples, affiliated with an already accredited public or private entity at the regional or national level.
Federated connection among biobanks: Create or modify existing biobank networks for new purposes or technologies, improving quality control measures and establishing data-sharing protocols.
Expected Results:
Creation of a minimum common information set among the different operating units to collect the same information and define a list of histotypes.
Definition of standard operating procedures (SOPs) for the management, storage, and sharing of samples and associated data.
Acquisition of facilities and personnel to manage the new biobank at UO3.
Digital pathology system and certified courier to share samples in each elected biobank.
This project represents a significant step towards creating a national biobank network for musculoskeletal sarcoma patients, improving the quality and quantity of samples available for research and facilitating knowledge sharing among specialized centers.
Financial Support
PNRR, financed by Ministero della Salute
The total grant of the project is: € 983.330,00
The grant assigned to IFO – IRE is: € 261.080,00
Other Institution involved:AORN Santobono-Pausilipon, IRCCS-Istituto Tumori Giovanni Paolo II
The funding resources are from the public notice 2° Avviso pubblico per la presentazione e selezione di progetti di ricerca da finanziare nell’ambito del PNRR sulle seguenti tematiche:
- Proof of concept (PoC);
- Tumori Rari (TR);
- Malattie Rare (MR);
- Malattie Croniche non Trasmissibili (MCnT) ad alto impatto sui sistemi sanitari e socio-assistenziali:
- Innovazione in campo diagnostico,
- Innovazione in campo terapeutico;
- Malattie Croniche non Trasmissibili (MCnT) ad alto impatto sui sistemi sanitari e socio-assistenziali:
- Fattori di rischio e prevenzione,
- Eziopatogenesi e meccanismi di malattia
Piano Nazionale di Ripresa e Resilienza - Missione M6 - Componente C2 - Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN finanziato dall’Unione europea - NextGenerationEU.