The “Digital Driven Diagnostics, pronostics and therapeutics for Sustainable Health care” project, acronym “D3 4 HEALTH” of which Sapienza is a public subject Coordinator and IFO-IRE IRCCS is affiliated Spoke -  is an innovative health ecosystem composed by 28 partners between public and private universities, research institutes and enterprises, It is engaged in enhancing research on digital technologies in the health sector, through a sophisticated data mining process, with the aim of improving diagnosis, monitoring and treatment.

The Foundation shall carry out activities aimed at promoting the dissemination of culture and scientific research for the benefit of society, as well as the cultural, social and economic development of the communities in which it operates and the exchange of knowledge and cooperation with enterprises, Public and private, national, EU, foreign or international institutions and institutes engaged in scientific and technological research in the health and care field.

Project start Date: 01/12/2022
Project end Date: 30/11/2025

The overall objective of the D3 4 HEALTH project is to deliver highly technological solutions that will impact the management of the reference disease: metastatic colon cancer, liver and bile duct cancer, central nervous system cancer, diabetes type I and multiple sclerosis. D3 4 HEALTH will fundamentally transform and advance current methodologies the diagnosis, monitoring and therapy of the reference disease facilitating the application of precision medicine approaches through the development of the digital and biological twins, for the benefit of citizens and patients. D3 4 HEALTH will escalate and deploy innovative and non-invasive technologies and solutions, based on the analysis of digital and digitalized healthcare data.

The specific objectives of D3 4 HEALTH will be achieved vertically and will be applied transversally to the 5 reference diseases, all with overarching activities. The four core Spokes are so characterized:

IFO-IRE as Affiliated Spoke participates with its research activities within the Spoke 1 and 2 of the project.

Contacts:

Scientific Director: Prof. Gennaro Ciliberto, gennaro.ciliberto@ifo.it

For the spoke 4: Dr. Giovanni Blandino, giovanni.blandino@ifo.it

For the Spoke 1: Dr. Antonello Vidiri, antonello.vidiri@ifo.it

The deployment of the proposed solutions will have direct and indirect effect on the three axes around which the NRRP was built: promote digitalization and innovation, improve the Italian ecologic transition and advance social inclusion, especially concerning the North-South gap and ensuring equality in accessibility to the best care to all citizens. An increase in public and private investment in R&D is expected given an effective collaboration between the public scientific base and the industrial world and the development of researchers' skills, particularly in digital technologies, environmental transition and management models provided in D3 4 HEALTH. The digital and biological twins proposed in the D3 4 HEALTH initiative will lead to better patient management and care, both in the shortand long-term. D3 4 HEALTH will achieve the goals of the national health system through the development of a research and clinical care digitized infrastructure, merging highly specialized technological centers and human expertise, based on an innovative model of integration of health data, for the development of state-of-the-art service delivery systems. Finally, D3 4 HEALTH will strengthen the position of Italy in the landscape of European technological advancement for the diagnostic and therapeutic reference diseases pathways and will impact the centrality of the person, the protection of the right to health, the collaboration between different levels of government, the optimization of resources and the return of health to the population.